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RASA SHASTRA

PAPER-I

 

Adharabhuta Siddhant, Rasa Chikitsa and Pharmacy Management

 

PART-A 

 

Adharabhuta Siddhant and Rasa Chikitsa

 

History and Chronological evaluation of Rasa shastra, Concept of Raseshwar darshan  and study of Rasa granthas with special emphasis on Rasarnava, Rasahridaya tantra, Rasa Ratna Samucchaya, Sharngadhara Samhita, Rasendra Chintamani, Rasa Ratnakar, Rasadhyaya, Rasa Kamdhenu, Anandkanda, Ayurveda Prakash, Bhavaprakash, Rasatarangini and Relevant portions of Brihatrayi

Concept of Rasamandapa and establishment of Rasashala in accordance with GMP.

Fundamental Principles of Rasashastra  and Bhaisajya kalpana including principles of designing different formulations with reference to Samslesha Vishleha and other principles.

Study of ancient and metric systems of weights and measures including Kala mana with their correlation.

Technical terminologies (Paribhasha) used in Rasa shastra and Bhaishajya kalpana.

Concept of Kshetrikaran, Importance of association of Rasa with Loha and Rasa-abhraka with loha (Rasyoga and Rasabhrayog), Study of Kramana(Anupana) yoga as described in Rasa Ratnakar, Rasayan khanda and Ananda kand, Study of  Ashuddha, Apakva, Avidhi sevita Rasa dravya sevana dosha and its management. Concept of lohajirna and Rasajirna.

 

PART - B 

Pharmacy Management

Management of Pharmacy, Store and Inventory Management, Personnel Management, Good Manufacturing Practices related to Ayurvedic Drug Industry.

Marketing Pharmaceutical Services

Product Release and Withdrawals

Community Pharmacy

Laws Governing Pharmacy

Relevant regulatory provisions of Ayurvedic drugs in Drug and Cosmetic Act 1940 and Rules 1945

Laws pertaining to Drugs and Magic remedies (objectionable advertisement) Act-1954.

Prevention of Food Adulteration (PFA) act.

Laws pertaining to Narcotics

Factory and Pharmacy Acts

Consumer Protection Act -1986

Regulatory Affairs related to International Trade and Practices of Ayurvedic Drugs.

Introduction to Ayurvedic Pharmacoepia of India, Ayurvedic Formulary of India.

Introduction to Indian Pharmacoepia, British and United States Pharmacoepia, Pharamcoepial Codex.

Introduction to Traditional Knowledge Digital Library

 

PAPER-II

Aushadh Prasamsaskaran evam Rasa  dravya Vigyan

 

PART-A

 

Aushadh  Prasamsaskaran dravya Vigyan

 

Detailed knowledge of ancient and contemporary Yantropakarana and their accessories used in Aushadhikaran and their contemporary modification such as yantras, mushas, putas, Koshthis, Bhrashtris, Muffle furnaces and other heating appliances, ovens, driers etc. used in manufacturing of Rasaushadhis in small scale and large scale along with their applications.

Study of Samskara, definition, types and its effect on Physico- chemical and Therapeutic properties of Samskararha dravya.
Role of Agni (Heat), Jala and other dravas (Water and other processing liquids), Kala (Time span), Patra (Container) and other processing materials and their significance in Aushadhikaran.

Detailed Knowledge of Shodhana with special emphasis on Shodhan dravya, instrumentation and processing techniques in relation to Shodhya dravya.

Study of Mardana and its significance in Aushadhikaran. Concept of Bhavana, detailed knowledge of ancient and contemporary grinding and trituration techniques.

Concept of Puta, definition, types and specifications of different Putas. Significance of different Putas in relation to Bhasmikaran and therapeutic efficacy of dravya under process. Bhasma pariksha vidhi and its significance in relation to contemporary testing procedures

Detailed Knowledge of Marana, with special emphasis on Marak dravya, Instrumentation, Processing technique in relation to Martya Dravya.

Detailed knowledge of Amritikaran and Lohitikaran and its significance in preparation of Bhasma with reference to dravya under process.

Detailed knowledge of Satvapatan; Shodhan, Mridukaran and Maran of Satva, its significance, in relation to therapeutic efficacy of dravya under process.

Detailed knowledge of Druti, its processing and its significance in relation to therapeutic efficacy.

Concept of Jarana, Moorcchana, Bandhan, Pakshaccheda and Maran in relation to Parad.

 

PART –B

Rasa dravya Vigyan

Detailed ancient and contemporary knowledge of Parada and its compounds with reference to Source, Occurrence, availability, Physico-chemical characterization, Grahya Agrahyatva, Shodhan maranadi vidhi, Therapeutic Properties and uses.

Detailed  ancient & contemporary knowledge with Geochemical/mineralogical/Biological identification, source, occurrence, availability, physico-chemical characterization, grahya-agrahyatva, Shodhan Maranadi Vidhi and Therapeutic properties and uses of dravyas included in Maharasa, Uparasa, Sadharana rasa, Dhatu, Upadhatu, Ratna, Uparatna, Visha, Upavisha, Sudha varga, Lavan varga, Kshar Varga and other varga used in Rasashastra.

Detailed knowledge of Standard Operating Procedure of manufacturing, Standardization, Quality control, Storage, therapeutic efficacy, Mechanism of action, Dose, Anupan and Method of administration of following Bhasma and pishti viz:

Bhasma - Abraka Bhasma, Svarnamakshika Bhasma, Kasis Bhasma, Svarna Bhasma, Rajat Bhasma, Tamra Bhasma, Loha Bhasma, Mandur Bhasma, Naga Bhasma, Vanga Bhasma,Yashad Bhasma, Trivanga Bhasma, Pittal, Kamsya and Varthaloha Bhasma,  Shankha Bhasma, Shukti Bhasma, Kapardika Bhasma, Godanti Bhasma, Praval Bhasma, Mrigashringa Bhasma, Mayurpiccha Bhasma, Kukkutand twaka Bhasma, Hiraka Bhasma, Manikya Bhasma.

 

Pishti - Praval pishti, Manikya Pishti, Mukta Pishti, Jahara mohara pishti, Trinakanta mani pishti.

 

Principles of Aushadhi Path Samyojan, Standard Operating Procedure of Preparation, Quality Control, Storage and Stability  of  Kharaliya, Parpati, Kupipakwa and Pottali Kalpa.

PAPER- III

 

Aushadha Yoga Vigyan

 

PART- A

Rasa Yoga Vigyan

 

Detailed knowledge of Aushadhi Patha Samyojan, Therapeutic efficacy, Mechanism of action, Dose, Anupan and Method of administration of following Aushadhi Yogas

 

Kharaliya Yoga

Shwasakuthara Rasa, Tribhuvanakirti Rasa, Higuleshwara Rasa, Anandabhairava Rasa, MahaLakshmivilasa Rasa, Vasnathakusumakara   Rasa, Vasantamalti Rasa, Bhrihatvata chintamani Rasa, Laghusutashekhar Rasa, Sutashekhar Rasa, Ramban Rasa, Chandrakala Rasa, Yogendra Rasa, Hridyarnava rasa, Grahanikapata Rasa, Garbhapala Rasa, Jalodarari Rasa, Mrityunjaya Rasa, Madhumalini vasanta Rasa, Arshakuthara Rasa, Krimimudgara Rasa, Suchikabharana Rasa, Trinetra Rasa, Smrutisagara Rasa, Vatagajankusha Rasa, Agnikumar Rasa, Ekangavir Rasa, Kamadudha Rasa, Purnachandrodaya Rasa, Prataplankeshwara Rasa, Mahavata vidhwansaka Rasa, Kasturibhairava Rasa, Ashwakanchuki Rasa, Gulmakuthara Rasa, Mahajwarankusha Rasa, Chandramrita Rasa, Kaphaketu Rasa, Prabhakara Vati, Pravala Panchamrita, Gandhaka Rasayana, Chaturbhuj rasa, Navajivan rasa, Shonitargal rasa, Raktapitta kulakandan rasa, Amavatari Rasa, Kravyada Rasa, Garbhachintamani Rasa, Chintamani Rasa, Trilokyachintamani Rasa, Pradarantaka Rasa, Vangeshwara Rasa, Brihatvangeshwara Rasa, Shwasakasa Chintamani Rasa, Smritisagar Rasa, Arogyavardhini Vati, Chandraprabha Vati, Agnitundi vati, Shankha Vati.

 

Loha Kalpa

Ayaskriti, Loha Rasayana, Amlapittantaka loha, Chandanadi loha, Dhatri loha, Navayasa loha, Putapakva vishamajwarantaka loha, Shilajatwadi loha, Tapyadi loha, Saptamrita loha, Amlapittantaka loha, Chandanadi loha, Dhatri loha, Punarnava Mandura, Amritasara Loha, Shankaramat loha, Pradarantaka loha, Rohitaka loha.

 

Kupipakva Yoga

Rasa Sindura, Makaradhwaja, Sidhamakaradhwaja, Samirapannaga Swarnavanga, Malla sindura, Rasa karpura, Rasa pushpa, Manikya Rasa.

 

4. Parpati Yoga    

Rasa Parpati, Loha Parpati, Tamra Parpati, Suwarna Parpati, Gagana Parpati, Vijay Parpati, Panchamrit Parpati, Shwet Parpati, Bola Parpati .

 

Pottali Yoga

Rasagarbhapottali, Hemagarbhapottali, Mallagarbha pottali,  pottali, Hiranyagarbha pottali, Shankagarbha pottali, Lokanatha rasa, Mriganka Pottali.

 

PART –B

Bhaishajya Yoga Vigyan

 

Detailed knowledge of Aushadhi Path Samyojan, Therapeutic efficacy, Mechanism of action, Dose, Anupan and Method of administration of following Aushadhi Yogas:                 

Panchavidha Kashayas and their Upakalpa

Ardraka swarasa, Tulasi swarasa, Vasa putapaka swarasa, Nimba kalka, Rasona kalka, Kulattha Kwath, Punarnavasthaka kwatha, Rasna saptaka kwatha, Dhanyak hima, Sarivadi hima, Panchakola phanta, Mustadi pramathya, Kharjuradi mantha, Shadanga paniya, Laksha rasa, Ajamoda arka, Yavanyadi arka, Chincha panaka, Candana panaka, Banapsha sharkara, Nimbu sarkara, Darvi rasakriya, Amrita satva, Ardraka satva, Arjuna kshirapaka, Rasona kshirapaka,

 

Pathya Kalpana

Yavagu, (Krita and Akrita), Ashtaguna manda, Laja manda, Peya, Vilepi, Krishara, Yusha,  Mudga yusha, Kulattha yusha, Saptamushtika yusha, Khad, Kambalika, Raga, Shadava Mamsarasa, Veshavara,  Takra, Udasvita, Katvar, Mathita, Chhacchika, Dadhi, Tandulodaka, Neutraceuticals and Food Supplements

Churna

 

Sitopaladi Churna, Talisadi Churna, Triphala Churna, Hingvashtaka Churna, Yashtimadhu Churna, Avipattikara Churna, Swadishta Virechana Churna, Trimada Virechana Churna,

Lavana Bhaskar Churna, Sudarshana Churna, MahaSudarshana Churna, Gandharva Haritaki Churna, Navayasa Churna, Pushyanuga Churna, Ajamodadi Churna, Hingvadi Churna, Eladi Churna, Dadimashtaka Churna, Trikatu Churna, Vaishwanara Churna

 

Gutika

Arogya vardhani vati, Chandraprabha vati, Chitrakadi Gutika,, Sanjivani Vati, Lasunadi vati, Lavangadi Vati, Vyoshadi vati, Khadiradi Vati,  Kankayan Vati, Abhayadi modak, Marichyadi gutika, Amalakyadi gutika, Samshamini Vati, Kutaja Ghana vati

4. Guggulu

Yogaraja Guggulu, Maha yogaraja Guggulu, Trayodashanga Guggulu, Kanchanara Guggulu, Rasnadi Guggulu, Triphala Guggulu, Simhanada Guggulu, Gokshuradi Guggulu, Kaishora Guggulu, Panchatikta Guggulu, Amritadi Guggulu, Vatari Guggulu, Lakshadi Guggulu, Abha Guggulu

 

Snehapaka

 

Sneha Moorchhana - Ghrita Murchana, Taila Murchhana

 

Siddha Ghrita-  Shatavari Ghrita, Jatyadi Ghrita, Phala Ghrita, Dadimadi Ghrita, Kshira Shatpala Ghrita, Triphala Ghrita, Dhanvantri Ghrita, Amritaprasha Ghrita, Kalyanaka Ghrita, Brahmi Ghrita, Changeri Ghrita, Panchatikta Ghrita, Sukumara Ghrita

 

Siddha Taila - Maha Narayana Taila, Maha Masha Taila, Bala Taila, Nirgundi Taila, Shadbindu Taila, Vishagarbha Taila, Sahacharadi Taila, Jatyadi Taila, Apamarga Kshara Taila,Tuvaraka Taila, Kshirabala Taila, Lakshadi Taila, Anu Taila, KumKumadi Taila, Hingutriguna Taila, Kottumchukadi Taila, Prasarinyadi Taila, Dhanwantari Taila, Balashwagandhadi Taila, Balaguduchyadi Taila, Nilibhringyadi Taila,  Brihadavadi Taila, Irimedadi Taila, Chandanadi Taila, Panchaguna taila, Arka taila

 

Avaleha

Vasa Avaleha, Brahma rasayana, Chyavanprasha Avaleha, Kushmanda Avaleha, Vyagri Haritaki Avaleha, Dadima Avaleha, Bilvadi Avaleha, Kantakaryavaleha, Haridra Khanda, Narikela khanda, Saubhagya shunthi paka.

 

Sandhan Kalpa

 

Shukta- Ikshu shukta, Tushambu, Kanjik, Sandaki

 

Madya - Sura, Shidhu, Varuni

 

Asava Arishta - Lodhrasava, Kumaryasava, Ushirasava, Chandanasava, Kanakasava, Sarivadyasava, Pippalyasava, Lohasava, Vasakasava, Kutajarishta, Draksharishta, Raktamitrarka, Dashamularishta, Abhayarishta, Amritarishta, Ashokarishta, Sarasvatarishta, Arjunarishta, Khadirarishta, Ashwagandha Arishta, Vidangarishta, Takrarishta.

 

8. Miscellaneous - Phala varti, Chandrodaya varti, Arka lavana, Narikela lavana, Triphala masi, Apamarga kshara, Snuhi kshara, Ksharasutra, Atasi upanaha, Sarjarasa malahara, Gandhaka malahara,Sinduradi Malahar, Shatadhouta Ghrita, Sahasra Dhouta Ghrita, Sikta taila, Dashanga lepa, Doshaghna lepa,  Bhallataka taila, Jyotishmati Taila, Bakuchi Taila, Dashanga dhupa, Arshoghna dhupa, Nishadi Netra bindu, Madhutailika Basti, Sneha Basti, Matra Basti, Yoga Basti, Karma Basti, Kala Basti.

 

PAPER -IV

Pharmaceutical Science

PART- A

Pharmaceutical technology

 

1.    

Scope and Evolution of Pharmacy

2.    

Information Resources in Pharmacy and Pharmaceutical Science

3.    

Posology

4.    

Colloidal and Coarse dispersion and Pharmaceutical Rheology

5.    

Preformulation

6.    

Separation

7.    

Principles of Distillation, Methods of Extraction, Infusion, Decoction, Maceration, Percolation and Fusion.

8.    

Sterilization & Sterile products, Ophthalmic and Parenteral Preparations 

9.    

Preservation and stabilization of pharmaceutical products

10.         

Drying, Open and Closed Air drying, Freeze drying, Vacuum drying and other drying methods

11.         

Pharmaceutical Excipients

12.         

Oral Solid Dosage Forms, Powder,   Size reduction & size separations,    Principles of mixing Micrometrics- Methods of determination of particle size, shape & Surface area, Methods of compression & Consolidation of powder solids, Tablets, Sustained release dosage forms, Suppositories & Pessaries, Capsules- Hard capsules & soft gelatin capsules & micro encapsulation

13.         

Semisolid Dosage Forms Emulsion, Suspensions and Extracts

14.         

Liquids - Solution, Solubility Phenomenon, Diffusion & Dissolution, pH, Buffers & Isotonic solutions, Clarification & Filtration: Techniques of filtration & Centrifugation, Syrup, Elixirs

15.         

Pharmaceutical aerosols

16.         

Topical drugs and Cosmetics

17.         

Packaging Materials and Labeling

18.         

Standardization of Raw material, In process Material and Finished Product

PART – B

 

Pharmacology & Toxicology

 

Pharmacology

 

Principles of Pharmacology

Pharmcodynamics & Pharmacokinetics: Absorption, distribution, mechanism of action & Excretion, Dose response relationship, structure activity relationship

Routes of administration of drug

Factors modifying drug effect, Drug interactions, Adverse drug reaction and Drug toxicity

Detailed Knowledge of Pharmacovigilance – National and International Scenario. Pharmacovigillance of Ayurvedic Drugs

Clinical pharmacology: Preclinical & clinical evaluation,         Bioavailability and Bioequivalence

 

Toxicology

 

Principles of Toxicology

Toxicology of Metallic, Mineral, Plant & Animal products

General principles of Management of Acute and Chronic Toxicity

 

Practicals

 

Minimum 150 practicals to be performed covering all the dosage forms. Educational Visits to minimum Five(5) GMP approved Ayurvedic Pharmacies

 

Ten days posting in R&D / Production unit in Ayurvedic Pharmacy.

 

Reference Books

Rasendra Chintamani

Rasakamadhenu

Rasaratna Samucchaya

Anand Kanda

Rasarnava

Bharatiya Rasashastra                                 - Vishvanath Dwivedi 

Rasa – Bhaishajya Kalpana Vigyan                            - Santosh Khandal

Modern texts related to Rasashastra

Rasahridaya tantra

Rasa Ratnakar

Arka Prakash

Rasatarangini

Rasajala Nidhi

Kupipakwa Rasayana                                           – Harisharananand

Parad Vigyaneeyam                 – Vasudeva Moolashankar Dvivedi

Rasaadhyaya

Rasa Chandanshu

Chakradatta                                   – Ratnaprabha commentary

Gada Nigraha

Vangasena

Vaidyaka Paribhasha Pradeepa

Rsayoga Sagara

Bhasma Vigyan                                           – Harisharananand

Ratna Dhatu Vigyan                             – Badrinarayana Shastri

Remington: Science and Practice of Pharmacy

Industrial Pharmacy                                                  – Lackma

Text Book of Phrmacology                      – Goodman and Gilman

Dana’s Text Book of Minerology

Quality Control of Ayurvedic Drugs            – PLIM, Gaziabad publication

Ayurvedic Pharmacopeia of India

Ayurvedic Formulary of India

Indian Pharmacopeia

British Pharmacopeia

United States Pharmacopeia

Pharmacopeia Codex

Current Good Manufacturing Practices

Drugs and Cosmetic Act 1940 and Rules 1945

Drugs and Magic remedies (Objectionable advertisement) Act-1954

Prevention of Food Adulteration (PFA) act

Laws pertaining to Narcotics

Factory and Pharmacy Acts

Consumer Protection Act -1986

History of Hindu Chemistry                                        – P. C. Roy

Ayurvedeeya Shodhan Vidhi                –Dhootpapeswar Publication

Siddha Yoga Samgriha                                –Yadavaji Trikamji Acharya

Rasamritam                                       - Yadavaji Trikamji Acharya

Dravyaguna Vijnan Pat-1 and 2             - Yadavji Trikamji Acharya

Dravyaguna                                – Chakradatta CCRAS Publication

Sahasrayoga

Rasa-tantra sara evam Siddha prayoga Sangriha       – Krishnagopal Kaleda publication

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